Ausbildung
1988: Diplom in Biologie II an der Uni Basel, Diplomarbeit über Zuckerstoffwechsel in Hefe
1993: Dissertation in Biochemie am Biozentrum der Uni Basel über Fruktan-Synthese in Gerste
Anstellungen
1993-96: Postdoc bei Sandoz (Toxikologie, Analytische Chemie)
1997-2004: Assistent am Institut für Pharmakologischen Biologie der Uni Basel
2005-12: Mitinhaber Schötzau & Simmen, Statistische Beratung, Basel
seit 2012: Inhaber eines Statistikbüros
Durchgeführte Projekte
- Zusammenarbeit mit zahlreichen universitären und pharmazeutischen Institutionen
- Diverse eigene Forschungsprojekte in den Bereichen klinische Studien, Pflanzenphysiologie, pharmakologische Wirkung von Arzneipflanzen
Verschiedenes
- Vorstand Pro Bilche
Ausgewählte wissenschaftliche Publikationen
Stutzki R, Weber M, Reiter-Theil S, Simmen U, Borasio GD, Jox RJ. Attitudes towards hastened death in ALS: A prospective study of patients and family caregivers. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2014; 15:68-76.
Lardi AM, Myrick ME, Haug M, Schaefer DJ, Bitzer J, Simmen U, Güth U. The option of delayed reconstructive surgery following mastectomy for invasive breast cancer: why do so few patients embrace this offer? Eur J Surg Oncol. 2013; 39(1):36-43.
Rohacek M, Bertolotti A, Grützmüller N, Simmen U, Marty H, Zimmermann H, Exadaktylos A, Spyridon A. The challenge of triaging chest pain patients: the bernese university hospital experience. Emerg Med Int. 2012.
Simmen U, Kelber O, Okpanyi SN, Jaeggi R, Bueter B, Weiser D. Binding of STW 5 (Iberogast) and its components to intestinal 5-HT, muscarinic M3, and opioid receptors. Phytomedicine. 2006;13 Suppl 5:51-5.
Simmen U, Saladin C, Kaufmann P, Poddar M, Wallimann C, Schaffner W. Preserved pharmacological activity of hepatocytes-treated extracts of valerian and St. John's wort. Planta Med. 2005 Jul;71(7):592-8.
Baur R, Simmen U, Senn M, Séquin U, Sigel E. Novel plant substances acting as beta subunit isoform-selective positive allosteric modulators of GABAA receptors. Mol Pharmacol. 2005 Sep;68(3):787-92.
Roos G, Röseler C, Büter KB, Simmen U. Classification and correlation of St. John's wort extracts by nuclear magnetic resonance spectroscopy, multivariate data analysis and pharmacological activity. Planta Med. 2004 Aug;70(8):771-7.
Simmen U, Bobirnac I, Ullmer C, Lübbert H, Berger Büter K, Schaffner W, Schoeffter P. Antagonist effect of pseudohypericin at CRF1 receptors. Eur J Pharmacol. 2003 Jan 5;458(3):251-6.
Hoffmann M, Verzijl D, Lundstrom K, Simmen U, Alewijnse AE, Timmerman H, Leurs R. Recombinant Semliki Forest virus for over-expression and pharmacological characterisation of the histamine H(2) receptor in mammalian cells. Eur J Pharmacol. 2001 Sep 14;427(2):105-14.
Simmen U, Higelin J, Berger-Büter K, Schaffner W, Lundstrom K. Neurochemical studies with St. John's wort in vitro. Pharmacopsychiatry. 2001 Jul;34 Suppl 1:S137-42.
Simmen U, Burkard W, Berger K, Schaffner W, Lundstrom K. Extracts and constituents of Hypericum perforatum inhibit the binding of various ligands to recombinant receptors expressed with the Semliki Forest virus system. J Recept Signal Transduct Res. 1999 Jan-Jul;19(1-4):59-74.
Simmen U, Obenland D, Boller T, Wiemken A. Fructan Synthesis in Excised Barley Leaves (Identification of Two Sucrose-Sucrose Fructosyltransferases Induced by Light and Their Separation from Constitutive Invertases). Plant Physiol. 1993 Feb;101(2):459-468.